1 Large Texture or Multiple Smaller Ones

Basically I am creating an interface and I am wondering if I should be using one big texture for the background image of the interface or if it should be made up of smaller images? What would be more beneficial in terms of performance?

For example from Heroes of Newerth, that big section on the bottom, specifically the backdrop, im not talking about the buttons and the health and all just the background image everything sits on.

Well if the whole image is visible then you might as well make it a big texture. If parts of it are offscreen then you may be better off splitting the geometry up into smaller parts with separate textures so that Unity can cull the parts which are not showing.

Depends on the hardware. I know my macbook doesnt seem to mind the number of draw calls. My old PC however simply can not process anything beyond say 80 calls a second (without dropping below 60 fps).

What is the lowest hardware you are targeting.