Any tips on creating tile-based obstacles/enemies in a 2D endless runner?

I am trying to create my first game in Unity and I decided on making it an endless runner. Now, I can’t quite figure out how to create tiles with obstacles and make them spawn randomly throughout the level and I couldn’t find much online that would suit my need. Any advice?

Check out the game in my signature.

It is a Infinite Runner game.

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Thanks!