Build for iPad2 and newer?

Would it be financial suicide to not release an iPad1 version of my game and
build for ipad2,3 and iPhone4s only?
Performance issues on iPad1 are causing delays.

I do not think so. Generally, consumers have gotten to into the tradition of upgrading (mobile) computers every second year or every year (my camp).

Personally, i would say just to go with the newer iPads. However, I would suggest having the game on the iPhone 4 as well. At least here in the US, the iPhone 4 is still very popular and still has people who purchased it as ‘new’ (ie. before the 4S) who will be tied to it for another year.