button has no reposne

yestoday everything goes well,I build a apk today, it works well on Andriod,but the UGUI has no response at all on PC in ediitor, what hell happens?

Dose it start to work if you relaunch Unity? I had same problem but did not yet find solution :frowning:

I try everything i can,restart unity,create a new Unity Proj, when i clear the Atalas cache,a new Canvas with native Button can work,but when i load my custom canvas,the button failed,
But…
In the morning,I Did something,maybe modify a shader used by the UI elelemnt,accdiently,I found everything goes well,the buttons has response again,so werid,I am not sure if it is related to the custom shader i made, I cant reproduce that jerk

The UGUI failed to work,has no response again(there is a fatal error of mono happens,not sure it is related to ngui),the first play on pc today

I changed the SystemTime of my PC to tommorrow,it seems everything comes back

seems something related to atalas,when i import an new picture as spirite,it works again(even if the spirite was not used at all)