Can we click on any of the Gameobject

Hello everyone,
I am new to Unity. I had a question. Can we click on any of the gameobject when the play mode is on?
If it’s possible, can someone tell me, how could I do that?

Thanks in advance.

If you are asking about moving and change variable values from gameObjects when unity is currently playing you can do it from the Scene layer, if you are talking about the Game layer that is currently playing what you do with your codes/objects, you can click, but nothing will happen because i think you don’t code it.