I notice in my stats that I have two draw calls for a single mesh covered by a single material. I'm assuming that the second draw call is for UV set 2, but I haven't assigned a second UV set. What if I want to free up that second draw call by only using one UV set?
A mesh does not need to have a second UV set (and most meshes don't) - but also, a second UV set will not cause a second draw call. How many draw calls you get per mesh is instead dependent on the shader you use, and on the number of pixel lights and shadow casting lights applied on the mesh.