It is hard to answer in relation to SmartFox but I know for ElectroServer, another option and a high-end multiplayer server solution, working with Unity's C# and/or JS, they play and talk nicely back and forth. In general, I would say the general rules of engagement outlined by Unity for internal working would hold true. HTH.
No it dosent i used it it just says complected things like a cilent server or a open server i recommend u use pro because it dosent have much java script hope i helped