Game Size in pixels

I’m a super newb. My question might not even make sense.

Imagine I want a 1024x768 pixel game with every solid object (walls, players, enemies) equal to 64 pixels.
I don’t care if in reality things are bigger than this and just scaled down for better quality or however it works.

What I want to know:
First: How to make sure the game world fits this scale.
Second: How to EASILY align sprites to at 64px grid.

And if what I’m asking doesn’t really work, what is my next best option within Unity?