Getting an attack to hit specific area

Third person adventure game.
Imagine you had a very large Ogre/Troll/cloverfieldmonster/RandySavage here, and he’s angry.
He sees the player.
Registers the players current position as “HitThisArea
Lifts his big Macho-Man-Randy-Savage arm into the air in a fist.

How can I get the fist to land on the “HitThisArea” transform?
What methods are generally used to achieve this method? Would it involve changing the keyframe for the monster’s fist of the attack at runtime?

Thanks for your help guys and gals. Hope this is the right subforum to ask for help.

Picture related: Imgur: The magic of the Internet

If you haven’t solved - look into IK in the documentation.