GUI for a diablo style game

No doubt this question has been asked a lot, and I’m sorry in advance if it has (I couldn’t find anything).

But can anyone give me any suggestions / tips on the best way to go about making a gui for attack abilities like in games such as WoW / Diablo / Torchlight etc?

Never really used Unitys GUI system this in depth before and I could use the advice.

Could you supply some screenshots on what exactly you are trying to accomplish?

Sorry, that would have made more sense. So you can see your health and mana guages. Skill buttons etc.

Something like this:

Well the first step would probably be not to use Unity’s GUI for something so complex. Have you checked out NGUI or any of the other GUI products in the Asset Store?

Another Vote for NGUI until Unity’s own new GUI System is out some day.
NGUI has a free version to try out and see if it suits you. I didn’t have the time to work on an actual project with it, yet but from the things I have seen and all the things developers who did use it told me it really is awesome. And you can work WYSIWYG.