3D stuff: camera FOV matching
2D stuff: camera orthoSize matching
UI stuff: anchoring and scaling. See below.
It’s always best to deal with it up front.
Here are the official docs on how to make your UI handle various resolutions and aspect ratios cleanly:
Here are some notes on UI Anchoring, Scaling, CanvasScaler, etc:
Usually you need to choose a suitable ScaleMode and MatchMode in the Canvas Scaler and stick with it 100%. Generally if you change those settings you will often need to redo your UI entirely.
I also use this CanvasScalerOrientationDriver utility to make sharing UI for Landscape / Portrait easier. Read what it does carefully.