Is there an advantage in using atlases for 2D animations instead of sprite sheets?

I’m using NGUI and its Atlas Maker. I found it practical and would like to know first if it’s possible to use an Atlas instead of a sprite sheet, for the purpose of 2d animations.

Also, is there any advantage in using atlases instead of sprite sheets?

These concepts are a bit confusing, I would appreciate if someone could help me out.

Thanks in advance

The ngui atlas is a sprite sheet itself, so you won’t see any rendering performance differences.

You might see some difference in the amount of computation it takes to switch frames in you animation. Switching ngui sprites probably has a bit more overhead than if you were directly manipulating your own sprite sheet.