Lots of busy... Hold on.... etc?

Another thread with the Application.Tick pop up. This sometimes takes 1 minute to finish for me. If it happens once a day that’s ok, but it happens whenever I edit script, enter\exit play mode or even edit prefabs. It adds up in a day. Sometimes 1 minute, sometimes 10 seconds… it’s hard to determine what is causing it.

6995807--829022--Screenshot 2021-04-05 194947.jpg