Making skybox textures with Substance

I was wondering if anyone has successfully used Substance to generate skyboxes? it seems a great tool for doing that sort of thing, but I cannot find any information on it.

I expect to do so you would need to make a huge image and output it as multiple smaller images or something similar, but any help or info on the above would be great, and if it is not possible then at least I know.

It can be done as long as the generated textures are tileable (I’ve done with a star substance called Space View). Create a new skybox of 6 images type and assign the generated texture to each of the images.