It means that an object is referenced somewhere in the code but the game cant find that gameobject since it returns null which is the indication that it does not exist , which means that you either had a GameObject or Behaviour variable and you did not get to define the object or behaviour you want it to reference in the inspector.
Alternatively , GameObject.Find functions return a nullreference exception if you try to access something from a found gameobject , but the game does not actually find it.
So if you dont have for example a gameobject named foo , GameObject.Find("foo").bar=3; would return a nullreferenceexception due to the fact that the variable bar does not exist in the inexistent gameobject.
You ought to provide us with the code that produces the error for more specific information though