Refresh gameObject to original prefab, but it isn't visible

Hello, so I’m making a RPG-type game where the “battle system” takes place within a UI prefab. However, it loads in data on Start(), which might change between uses within the same scene, so I wanted to have the UI spawn in a new instance of the prefab in its place and then delete itself. However, when I go to enter a “battle” a second time, it never shows up but it still seems to be functioning in some capacity (given activity in the log).
When I instantiate the second UI, do I need to alter it in some way to allow it to be seen, or is there some better way to do this?

EDIT:
Here’s what the original UI does when it’s time to close:

g.battle = false;
g.pList [0].battleBox = Instantiate(battlePrefab);
g.pList [0].battleBox.SetActive (false);
Destroy (gameObject);

“g” is just a class for global variables, and pList is the list of party members (with index 0 being the main character), so it’s basically replacing the old one (Which used to be in battleBox) with the new instantiated one, then setting the new one to be inactive until it’s needed, then destroying the old one.

After doing a bunch of messing around with it, I’ve figured out that somehow the newly instantiated UI just doesn’t exist at any point, as it doesn’t show up in the hierarchy when I pause. Does deleting the object which instantiated it delete the new one? Or is deleting the only instance of the prefab in the scene somehow deleting the whole prefab (and thus all other instances, or stopping them from being instantiated)?