Spine vs Anima2D - Working with a character that can change appearance

I recently posted a thread in the 2D forum. Since then I’ve spent a lot of time looking at my options and have concluded that Spine would be able to do what I need (create a skeleton for each body-part without having to worry about the attached sprite (cosmetics)).

But I would really prefer to work with Anima2D, for several reasons. So I will ask here, is there any way I can avoid creating a mesh for each sprite I’m going to use? And just set a “generic” skeleton for my naked character, and simply have whatever clothes (sprites) I put on him follow that skeleton? I don’t want to have to edit/manage > 500 sprites of different clothes as soon as I want to tweak an animation.

Since the documentation for Anima2D is a bit lacking I’m having trouble understanding if it’s possible or not. All tutorials I can find just create meshes for each texture.

@DominoM provided the answer to the question you are asking. If a ‘sprite’ will be attached to a bone - it has to be shown via some kind of renderer - That 'polygon/quad/mesh - will be what you map the sprite onto - and swap out sprites - as you wish.
If you can’t figure something out through documentation or tutorials - best to just give it a go - create a small simple test solution and run it through it’s paces - how you want it to work.