Sprite Mesh Type: Full Rect vs Tight (Mobile Performance)

In general, overdraw is bad for performance on low-end devices and some mobile devices will fall into that category.

By default when you import your Sprites into Unity, they should have their Mesh type set to “tight” so you shouldn’t have to change anything.

In that case you would probably be better off with a quad. If you want to do some micro-optimisation you could even draw an outline yourself in the Custom Outline section of the Sprite Editor.

Can you share how your Sprites are laid out in the Sprite sheet?