Unity 2018.2.6f1 - Fatar error / Failed to initialize player when launching game

Perhaps related to the following issue, which causes all sorts of odd errors and crashes:

A quick test to find out, whether it’s related to the size limit, would be to resize a lot of large textures (inside Unity) to 64x64 pixels for example, replace large sound files with silence, etc. Just to make sure to get the build size much smaller in a short amount of time.

If the game works with these modifications, then it’s probably related to the linked bug. In this case you might want to look into asset bundles, to by-pass this Unity limitation, as suggested in the linked forum thread.