For the UI:
Here are some notes on UI Anchoring, Scaling, CanvasScaler, etc:
https://discussions.unity.com/t/845782/4
https://discussions.unity.com/t/848795/5
For the sprites:
Everything is tied (by default) to camera .orthographicSize… go look at the docs, make a blank scene, drag some sprites in and fiddle with it… it will become obvious pretty soon how this size maps to vertical worldspace.