Unity Bugging out quite often- interface issues.

Hey there- so i’ve noticed Unity does this thing, usually after i’ve been using it for a while, and then I save. It goes from the normal interface, fonts, and so on, into this- that looks like the default GUI Skin.

Anyone else having this issue?

Unity 4.2.

I’ve had it happen a couple of times like a few weeks ago. Haven’t seen it since.