Ok, so I didn’t want to use UI Button since there seemed to be some redundant functionality in my case (for now, anyway), so I instead created some UI images, attaching a script that implements IPointerClickHandler’s OnPointerClick. Now everything is fine when I’m running either in the debugger or in windowed mode, but when I launch as fullscreen, the events fire, but they seem to be firing only when I click the wrong locations. The UI Images scale correctly, but on OnPointerClick isn’t firing when I click on them, but only from what I assume is their pre-scaled postion.

I’ve outlined the area’s where, if I click, will fire the OnPointerClick Events.

In Window’d mode:

In Fullscreen mode:

All my UI components are anchored to their top-left positions.
My canvas is set to scale with screen space.

Anyone got a hint as to what is going on?

Nevermind, from what I’ve looked at and the actions I’ve taken, it appears to be a known issue Unity Issue Tracker - Button position is wrong on fullscreen player which aspect ratio is different then monitor's
I’m running 5.1.1f