how can i lock an Gameobject by script ?

the gamobject should be Disappear from scene when you play the game
i used render component for hidden object but it’s not hide from mouse events


I sort of understand what you’re getting at, but in the future please format your question in a way everyone reading can understand. “Lock” really doesn’t pertain to this situation.

To completely disable a GameObject:
Click Here For GameObject.SetActive Documentation

If you still need the object to remain active, you can use your current method plus switching layers.
Click here for Layers Documentation