Hi all,
I had a link to this in my sig, but I’m about to change that, so I wanted to be sure to point this out in case anybody’s interested.
I recently did a fairly detailed comparison of three different approaches to 2D spritesheet animation in Unity. The article, 2D Animation Methods in Unity, was featured on Gamasutra. They don’t have the best code formatting, but you can download the complete demo project and peruse it on your own computer.

Or, if you’re in a dessert-first sort of mood, you can jump directly to the web player demo, and then go back to the article to understand how it works.
I hope this is useful to somebody… I know I sure learned a lot from doing it.
Cheers,
- Joe