How to make a 2D Collider NOT to collide with my "mouse click"?

Please help me! Thank you!

By default nothing can collide with your mouse click, exactly what are you trying to do and how are you trying to do it?

If you’re using another component on that object that has something like “Raycast target”, untick it.
If you’re not, we have to know what you do use for your mouse clicks, and what you do use combined to your Collider2D.